ARCHIVES OF INTERNAL MEDICINE
Alcoholic beverage consumption is causally related to a number of cancers including oral cavity, pharynx, larynx, esophagus, liver, colorectum, and female breast. However, it has never been linked definitively to pancreatic cancer despite the fact that heavy alcohol consumption is a cause of acute and chronic pancreatitis. The lack of convincing evidence is in part due to concerns about study design and potential residual confounding by smoking. The American Cancer Society's Cancer Prevention Study II is a large prospective study of more than 1 million adults, which began in 1982. After 26 years of follow-up, liquor consumption of 3 or more drinks per day was associated with an excess risk of pancreatic cancer mortality after adjustment for smoking history, as well as in lifelong never smokers. Overall, the design and size of this study help to resolve concerns about inconsistencies observed in other studies of the alcohol-pancreatic cancer association.
See article: http://archinte.ama-assn.org/cgi/content/abstract/171/5/444?view=short&fp=444&vol=171&lookupType=volpage
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